What is CrCl vs eGFR?

Creatinine clearance (CrCl) from Cockcroft-Gault estimates actual creatinine clearance. eGFR (CKD-EPI, MDRD) estimates GFR. CrCl is preferred for drug dosing, eGFR for CKD staging.

When should I use Cockcroft-Gault?

Most drug dosing guidelines use Cockcroft-Gault CrCl. FDA drug labels typically specify Cockcroft-Gault. Use actual body weight unless morbidly obese.

What weight should I use?

Use actual body weight. For obese patients (>20% above IBW), some use adjusted body weight: IBW + 0.4×(actual - IBW). Check specific drug recommendations.

Does age or gender matter?

Yes, the formula accounts for lower muscle mass in females (×0.85) and decreasing muscle mass with age. Both reduce expected creatinine production.

What about extremes of body size?

May overestimate in obese patients (use adjusted weight) and underestimate in amputees. Consider cystatin C-based equations in these cases.

Creatinine Clearance

Cockcroft-Gault equation for drug dosing.

Age

years

Patient age in years

Weight

Actual body weight. Use adjusted weight if obese.

Serum Creatinine

mg/dL

Serum creatinine level

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Creatinine Clearance

0.0 mL/min

Kidney Failure

CrCl

0.0 mL/min

Sex Adjustment

None

Cockcroft-Gault Formula

CrCl = [(140 - Age) × Weight] / (72 × SCr)

= [(140 - 65) × 70] / (72 × 1.2) = 0.0 mL/min

Frequently Asked Questions

About the CrCl Calculator

What it calculates

This crcl calculator applies a validated clinical scoring method used in healthcare settings. Cockcroft-Gault for drug dosing.

When to use it

Use as a clinical decision support aid alongside professional judgment — not as a standalone diagnosis.

Example

Adjust the inputs above to model your specific scenario with the CrCl Calculator.

Explore More

Creatinine Clearance

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0.0 mL/min

Kidney Failure

Cockcroft-Gault Formula

About the CrCl Calculator

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